Explain Why HIV Becomes Resistant So Quickly When a Single

question 96

Multiple Choice

Explain why HIV becomes resistant so quickly when a single drug is used therapeutically.

• A)The virus is an RNA genome virus-by using host RNA polymerase to directly copy the genome to make more virus particles,there's no proofreading capability.This leads to a high rate of mutation of the viral genome and increased chance for drug resistance.
• B)HIV utilizes reverse transcriptase to make a cDNA version of its RNA genome.This polymerase is "'sloppy," with a high rate of error and lack of a proofreading capability.This leads to a high rate of mutation of the viral genome and increased chance for drug resistance.
• C)HIV synthesizes a protein enzyme that directly cleaves anti-HIV drugs,giving it a characteristically high rate of resistance to a single drug type.
• D)HIV is constantly changing its genetic structure by swapping genetic elements with other virus strains.This leads to a high rate of mutation of the viral genome and increased chance for drug resistance.

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