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While we have seen how natural selection and the use of pesticides can lead to the development of resistant varieties of insects, two economically important flies, the Mediterranean fruit fly (Medfly) and the screwworm fly, can be driven to local extinction by the continuous release of sterile flies of those species. The critical factor is that the female of these species only mates once. But which of the following is/are also necessary for sterile release to work?
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