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Glucose (C6H12O6) Can Exist as Both an Open-Chain Form and a Closed-Ring

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Glucose (C6H12O6) can exist as both an open-chain form and a closed-ring form. Before 1900, glucose was only thought to occur as an open chain. Now we know that over 99 percent of the time, glucose occurs in the closed-ring form. What possible difference between these forms would give chemists a clue that the open-chain form was not present?


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