A Translocation Between Chromosomes 9 and 22 Produces the BCR-ABL $\alpha$

question 13

Multiple Choice

A translocation between chromosomes 9 and 22 produces the BCR-ABL fusion gene.This is the transforming event in 90% of individuals with chronic myelogenous leukemia (CML) .Which one of the following statements regarding the protein product of this fusion gene is correct?

• A) It is a nuclear phosphoprotein that deregulates DNA syntheses and increases cellular proliferation.
• B) It is a cytoplasmic tyrosine kinase that activates a number of signaling pathways leading to growth and inhibition of apoptosis.
• C) It is a mitotic control gene that allows cells to move through the cell cycle and contribute to the autonomous growth of cancer.
• D) It interacts with other proteins,such as \(\alpha\)- and \(\beta\)-catenin,involved in cell-cell interactions in epithelial cells to form polyps.

Know the objections to pluralistic and duty-based approaches in ethics.

Understand the concepts and types of microaggressions and their impacts on out-groups.

Identify and describe psychological techniques used in persuasion and commitment.

Recognize the role of attribution biases in prejudice and stereotype formation.

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Definitions:

Estimated Activity

An approximation of the level of operational or production activity expected in a certain period, typically used for budgeting and costing.

Unused Capacity

The portion of a company's production or operational potential that is not currently being utilized.

Predetermined Overhead Rate

A rate calculated before the period begins, used to allocate manufacturing overhead costs to products based on a particular activity base, such as machine-hours or labor-hours.

Automated Lathe

A CNC (Computer Numerical Control) machine tool used to shape metal, wood, or other materials by rotating it rapidly along its axis while pressing a fixed cutting or abrading tool against it.