Why Do Values Obtained with the Jaffe Reactions for Creatinine

question 2

Multiple Choice

Why do values obtained with the Jaffe reactions for creatinine measurement overestimate creatinine concentration by ~20%?

• A) The components of the reaction mixture often continue to react at endpoint and synthesize excess creatinine.
• B) The rate of Jaffe complex formation is temperature dependent,and excess heat formed by the reaction leads to increased absorptivity and falsely increased creatinine value.
• C) Noncreatinine chromogens in the reaction that react with the picrate in the end-point Jaffe methods overestimate true plasma creatinine concentration.
• D) Hydroxide concentrations above 0.5 mmol/L produce a decreased degradation of the Jaffe complex.

---

Definitions:

Mailbox Rule

The mailbox rule is a legal principle that an offer is considered accepted once the acceptance is properly placed in the mail, even if it is lost or delayed.

Effective Upon Dispatch

Effective upon dispatch refers to the principle that certain actions, such as the sending of a notification or document, are considered effective from the moment they are sent, not when they are received.

Reasonable Expectation

refers to what an average person might foresee or predict as a likely outcome under certain circumstances, often used as a standard in legal and ethical considerations.

Revocation

The official cancellation or withdrawal of an offer, license, right, or privilege.