Select the Mechanism of Action of the Glucocorticoids in the Suppression

question 7

Multiple Choice

Select the mechanism of action of the glucocorticoids in the suppression of the inflammatory response.

• A) The glucocorticoid hormone, ACTH, is transported to the target cell. ACTH passes through the plasma membrane into the cytoplasm, where it binds to the specific, high-affinity glucocorticoid receptor. The activated receptor-ACTH complex goes into the nucleus and binds to specific DNA elements to activate transcription of antiinflammatory proteins or prevent proinflammatory protein production.
• B) The glucocorticoid hormone, CRH, is transported to the target cell. CRH passes through the plasma membrane into the cytoplasm, where it binds to the specific, high-affinity glucocorticoid receptor. The activated receptor-CRH complex goes into the nucleus and binds to specific DNA elements to activate transcription of antiinflammatory proteins or prevent proinflammatory protein production.
• C) The glucocorticoid hormone, cortisol, is transported to the target cell. Cortisol passes through the plasma membrane into the cytoplasm, where it binds to the specific, high-affinity glucocorticoid receptor. The activated receptor-glucocorticoid complex goes into the nucleus and binds to specific DNA elements to activate transcription of antiinflammatory proteins or prevent proinflammatory protein production.
• D) None of these are correct.

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