Outline the Steps in the Mechanism of Action of Digoxin

question 5

Multiple Choice

Outline the steps in the mechanism of action of digoxin.

• A) Digoxin stimulates Na/K ATPase. Stimulation of Na/K ATPase increases intracellular concentration of Na⁺ ions. Increased intracellular Na⁺ decreases the Na⁺/Ca⁺⁺ exchanger and allows intracellular Ca⁺⁺ concentrations to increase. Increased intracellular Ca⁺⁺ increases the formation of actinomyosin and increases the force of myocardial contractions.
• B) Digoxin binds to and inhibits Na/K ATPase. Inhibition of Na/K ATPase decreases intracellular concentration of Na⁺ ions. Decreased intracellular Na⁺ increases the Na⁺/ Ca⁺⁺ exchanger and allows intracellular Ca⁺⁺ concentrations to decrease. Decreased intracellular Ca⁺⁺ increases the formation of actinomyosin and increases the force of myocardial contractions.
• C) Digoxin binds to and inhibits Na/K ATPase. Inhibition of Na/K ATPase increases intracellular concentration of Na⁺ ions. Increased intracellular Na⁺ decreases the Na⁺/ Ca⁺⁺ exchanger and allows intracellular Ca⁺⁺ concentrations to increase. Increased intracellular Ca⁺⁺ increases the formation of actinomyosin and increases the force of myocardial contractions.
• D) None of these are correct

---

Definitions:

Survey Research

A research method involving the collection of data from a predefined group of respondents to gain information and insights on various topics of interest through questionnaires or interviews.

Major Elections

Elections that are of significant national or regional importance, typically involving the choice of top government officials such as presidents, governors, or major legislative bodies.

Correlational Research

A type of non-experimental research method used to identify associations or relationships between two or more variables, without determining cause and effect.

Binge Drinkers

Individuals who consume large amounts of alcohol in a short period, often to the point of intoxication.