Explain the Reason Why Some Drug Agents Such as Phenytoin

question 12

Multiple Choice

Explain the reason why some drug agents such as phenytoin (Dilantin) and valproic acid (Depakene) can produce greater pharmacologic effects when administered with other drugs that are highly plasma protein bound.

• A) Phenytoin (Dilantin) and valproic acid (Depakene) cause microsomal enzyme induction, leading to a decrease in drug metabolism causing greater pharmacologic effect.
• B) Phenytoin (Dilantin) and valproic acid (Depakene) reduce the T-type calcium currents, leading to increased pharmacologic effect.
• C) Phenytoin (Dilantin) and valproic acid (Depakene) are also highly plasma protein bound, causing greater pharmacologic effect.
• D) None of these are correct.

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Definitions:

Sound Waves

Sonic oscillations transmitted through the air or other mediums, detectable upon reaching the ears of people or animals.

Carotid Canal

A passage in the temporal bone of the skull through which the internal carotid artery enters the cranial cavity to supply blood to the brain.

Internal Carotid Artery

A major artery located in the head and neck that supplies blood to the brain, eyes, eyelids, forehead, nose, and internal ear.

Carotid Canal

A passageway in the temporal bone of the skull that carries the internal carotid artery to the brain.