Which of the Following Reactions, If Coupled to the Reduction $\alpha$

question 22

Multiple Choice

Which of the following reactions, if coupled to the reduction of $\alpha$ -ketoglutarate, would give the most exergonic overall reaction? $\alpha$ -ketoglutarate + CO₂ + 2H⁺ + 2e^- $\rarr$ isocitrate (E ^$\circ$ ' = - 0.38 V)

• A)ubiquinol \(\rarr\) ubiquinone + 2H⁺ + 2e^- (E^\(\circ\)' = - 0.04 V)
• B)FADH₂ \(\rarr\) FAD + 2H⁺ + 2e^- (E^\(\circ\)' = + 0.22 V)
• C)NADH \(\rarr\) NAD⁺ + H⁺ + 2e^- (E^\(\circ\)' = + 0.32 V)
• D)H₂ \(\rarr\)2H⁺ + 2e^- (E^\(\circ\)' = + 0.42 V)
• E)pyruvate + CoA \(\rarr\) acetyl CoA + CO₂ + H⁺ + 2e^- (E^\(\circ\)' = + 0.48 V)

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