The Transcription Factor PGC-1 $\alpha$ Is Controlled by Two Forms of Covalent Modification

question 2

Multiple Choice

The transcription factor PGC-1 $\alpha$ is controlled by two forms of covalent modification. Which of the following correctly identifies a mechanism of control?

• A)phosphorylation by AMPK inhibits PGC-1\(\alpha\)
• B)dephosphorylation by AMPK activates PGC-1\(\alpha\)
• C)acetylation by SIRT1 activates PGC-1\(\alpha\)
• D)deacetylation by SIRT1 activates PGC-1\(\alpha\)
• E)dephosphorylation by AMPK and deacetylation by SIRT1 activates PGC-1\(\alpha\)

---

Definitions:

Rock Walls

Natural or man-made vertical structures made of rock, often serving as boundaries, fortifications, or geological features.

Continental Mantle Plumes

Upwellings of abnormally hot rock within the Earth's mantle thought to cause volcanic activity and continental breakup.

Explosive Eruptions

Volcanic eruptions characterized by violent explosions that eject ash, lapilli, and volcanic bombs into the atmosphere.

Felsic Magma

Magma that is rich in silica and light in color, with high viscosity and typically forms rocks such as granite and rhyolite.