Using the Following DNA Segment, Show How Microsatellite Instability Is

question 12

Essay

Using the following DNA segment, show how microsatellite instability is present through a 2-base deletion as a result of loop creation within the A-C repeating sequence. Give the sequence after the first round of replication (with loop)and after the second round of replication.
Template strand: 3'-C-A-C-A-C-A-C-A-C-A-5'

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Definitions:

Continuous Probability Distributions

Probability distributions in which the data can take infinitely many values within a given range.

Poisson Probability Distribution

A discrete probability distribution that expresses the probability of a given number of events occurring in a fixed interval of time or space, assuming these events occur with a known constant mean rate and independently of the time since the last event.

Binomial Probability Distribution

A probability distribution detailing the chances of a variable assuming one of two independent values based on specific parameters or assumptions.

Normal Probability Distribution

A bell-shaped probability distribution characterized by its mean and standard deviation, describing how random variables are distributed.