Methylation of Guanine to Produce O⁶-Methylguanine (MG)results in What Change $\rarr$

question 5

Multiple Choice

Methylation of guanine to produce O⁶-methylguanine (mG) results in what change to DNA?

• A)mG frequently pairs with thymine resulting in a GC \(\rarr\) AT mutation
• B)mG loses its methoxy group resulting in hydrogen bonding with adenine and a bulge in the double helix
• C)mG is prone to deamination and eventually, depurination
• D)repair of mG adducts uses a radical mechanism that has the potential to further damage adjacent bases, particularly thymine
• E)none of the above

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