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(Requires Appendix Material and Calculus)Equation (5 β\beta 1 to Be Var β\beta

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(Requires Appendix material and Calculus)Equation (5.36)in your textbook derives the conditional variance for any old conditionally unbiased estimator β\beta 1 to be var( β\beta 1  (Requires Appendix material and Calculus)Equation (5.36)in your textbook derives the conditional variance for any old conditionally unbiased estimator  \beta  <sub>1</sub> to be var(  \beta  1   X<sub>1</sub>, ..., X<sub>n</sub>)=  \sigma _ { u } ^ { 2 } \sum _ { i = 1 } ^ { n } a _ { i } ^ { 2 }  where the conditions for conditional unbiasedness are  \sum _ { i = 1 } ^ { n } a _ { i }  = 0 and  \sum _ { i = 1 } ^ { n } a _ { i } X _ { i }  = 1. As an alternative to the BLUE proof presented in your textbook, you recall from one of your calculus courses that you could minimize the variance subject to the two constraints, thereby making the variance as small as possible while the constraints are holding. Show that in doing so you get the OLS weights  \hat { a } _ { i }  (You may assume that X<sub>1</sub>,..., X<sub>n</sub> are nonrandom (fixed over repeated samples).) X1, ..., Xn)= σu2i=1nai2\sigma _ { u } ^ { 2 } \sum _ { i = 1 } ^ { n } a _ { i } ^ { 2 } where the conditions for conditional unbiasedness are i=1nai\sum _ { i = 1 } ^ { n } a _ { i } = 0 and i=1naiXi\sum _ { i = 1 } ^ { n } a _ { i } X _ { i } = 1. As an alternative to the BLUE proof presented in your textbook, you recall from one of your calculus courses that you could minimize the variance subject to the two constraints, thereby making the variance as small as possible while the constraints are holding. Show that in doing so you get the OLS weights a^i\hat { a } _ { i } (You may assume that X1,..., Xn are nonrandom (fixed over repeated samples).)

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Definitions:

Polygenetic Disorder

A disorder caused by the combined action of multiple genes, rather than a single gene mutation.

Biological Basis

The underlying physiological and genetic factors contributing to an organism's development and behavior.

Genetic Studies

Research focused on understanding how genes contribute to biological traits, including diseases, through the inheritance and variation of genetic information.

Delusional Disorder

A psychiatric condition characterized by the presence of delusions, which are fixed beliefs that conflict with reality but remain despite evidence to the contrary.

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