Hemoglobin Is a Model System to Illustrate the Deleterious Effects

question 44

Multiple Choice

Hemoglobin is a model system to illustrate the deleterious effects of mutations.Which of the following statements about deleterious mutations in human hemoglobin genes is false?

• A) Hemoglobin A and hemoglobin S differ at only one amino acid position
• B) In hemoglobin S, the substitution of valine for glutamic acid causes an aggregation of hemoglobin molecules not found in hemoglobin A
• C) The molecular difference between hemoglobin A and hemoglobin S was identified by protein sequence before nucleotide sequence
• D) The valine to glutamic acid substitution is the only amino acid change so far identified in the b chain of hemoglobin
• E) Homozygous (Hb^sb/Hb^sb) leads to severe hemolytic anemia, which is often fatal.

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