Dominant Alleles at Two Different Loci Affect the Tail of Mice.These

question 34

Essay

Dominant alleles at two different loci affect the tail of mice.These genes are linked and both are lethal in the embryo when homozygous.One of the tail genes is called brachyury (T),and these mice have short tails.A third gene,histocompatibility-2 (H-2),is linked to the tail genes and is concerned with tissue transplantation.Mice that are H-2/+ will accept tissue grafts,unlike +/+.A cross was carried out between male T H-2/ + + and female + +/+ + mice,and produced the following baby mice.
$$\begin{array} { l l } \text { Brachy tail, accepts graft } & 105 \\\text { Narmal tail, rejects graft } & 115 \\\text { Brachy tail, rejects graft } & 14 \\\text { Narmal tail, accepts graft } & \underline {1 6 }\\&250\end{array}$$
Determine if the linkage between H-2 and T is significant using the chi-square test.

---

Definitions:

Effective Interest Method

A technique used in accounting for amortizing the cost of a bond premium or discount over the life of the bond in a way that results in a constant rate of interest over the period.

Issuance

The process by which a company offers new or existing securities for sale to investors, including stocks or bonds, to raise capital.

Interest Payment

The amount paid by a borrower to a lender as compensation for the use of borrowed money, usually expressed as a percentage of the principal.