Dominant Alleles at Two Different Loci Affect the Tail of Mice.These

question 34

Essay

Dominant alleles at two different loci affect the tail of mice.These genes are linked and both are lethal in the embryo when homozygous.One of the tail genes is called brachyury (T),and these mice have short tails.A third gene,histocompatibility-2 (H-2),is linked to the tail genes and is concerned with tissue transplantation.Mice that are H-2/+ will accept tissue grafts,unlike +/+.A cross was carried out between male T H-2/ + + and female + +/+ + mice,and produced the following baby mice.
$$\begin{array} { l l } \text { Brachy tail, accepts graft } & 105 \\\text { Narmal tail, rejects graft } & 115 \\\text { Brachy tail, rejects graft } & 14 \\\text { Narmal tail, accepts graft } & \underline {1 6 }\\&250\end{array}$$
Determine if the linkage between H-2 and T is significant using the chi-square test.

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Definitions:

Negligence

The failure to exercise a level of care that a reasonably prudent person would under similar circumstances, leading to harm or damage.

Damages

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Actions or conduct that are considered appropriate and respectful within a society or group.

Reasonably Prudent Person

A legal standard that represents how an average person would responsibly act in certain circumstances.