Why Do Individuals Who Are Heterozygous for Sickle Cell Anemia

question 25

Multiple Choice

Why do individuals who are heterozygous for sickle cell anemia have a resistance to malaria?

• A)formation of hemoglobin aggregates makes red blood cells impervious to parasitic infection
• B)shortened life span of red blood cells does not allow sufficient time for the parasite to mature in the red blood cell
• C)diminished blood flow to the skin as a result of sickled red blood cells blocking capillaries prevents mosquitoes from actually transferring the malaria parasite to individuals
• D)sickle cell hemoglobin fibers have both decreased O₂ and CO₂ carrying capacity; since CO₂ is a mosquito attractant, diminished CO₂ exhalation does not attract mosquitoes
• E)none of the above

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