The Phosphorylation of Creatine (Cr)by ATP Forming Creatine Phosphate (Cr-P)is $\Delta$

question 1

Multiple Choice

The phosphorylation of creatine (Cr) by ATP forming creatine phosphate (Cr-P) is rather endergonic ( $\Delta$ G°´ = + 12.6 kJ/mol) . Which of the following explains how this reaction proceeds in a typical muscle cell?

• A)in the cytosol, [ATP] is high and [Cr] is high allowing the reaction to proceed
• B)in the mitochondria, [ATP] is high and [Cr-P] is low allowing the reaction to proceed
• C)Cr-P is rapidly transported across the cellular membrane allowing for high levels of Cr-P in the cytosol
• D)in the mitochondria, [ADP] is high allowing phosphorylation of Cr to occur
• E)none of the above

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