In the Regulation of Glutamine Synthetase Activity, an Important Regulatory $\alpha$

question 8

Multiple Choice

In the regulation of glutamine synthetase activity, an important regulatory protein, P_II exists in two states, one with UMP covalently bound (P_II-UMP) , the other without (P_II) . Which of the following statements regarding $\alpha$ -ketoglutarate and P_II is correct?

• A)\(\alpha\)-ketoglutarate binds to P_II causing inhibition of adenylyltransferase
• B)\(\alpha\)-ketoglutarate binds to P_II causing activation of adenylyltransferase
• C)\(\alpha\)-ketoglutarate binds to P_II-UMP causing inhibition of adenylyltransferase
• D)\(\alpha\)-ketoglutarate binds to P_II-UMP causing activation of adenylyltransferase
• E)\(\alpha\)-ketoglutarate does not bind to either form of P_II

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