Describe the Acid-Catalyzed First Slow Step in the Hydrolysis of an Ester

question 12

Multiple Choice

Describe the acid-catalyzed first slow step in the hydrolysis of an ester.

• A)The electron pair on oxygen forms double bond and alcohol is the leaving group.
• B)The base abstracts extra hydrogen from protonated alcohol.
• C)The oxygen of the carbonyl group abstracts a hydrogen from HB.
• D)Water attacks the carbonyl carbon and electron pair goes to oxygen.
• E)The oxygen on the alkoxy group abstracts a hydrogen from HB.

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Definitions:

Cystic Fibrosis

A genetic disease with an autosomal recessive inheritance pattern;

CFTR Protein

A protein that functions as a channel transporting chloride ions across cell membranes, mutations of which cause cystic fibrosis.

Genetic Disease

A disorder or condition caused by abnormalities in an individual's DNA, often inherited from one or both parents.

Amino Acid

An organic compound containing an amino group (—NH2) and a carboxyl group (—COOH); may be joined by peptide bonds to form a polypeptide chain.