Find the Jacobian of the transformation. 
Definitions:
TH-binding Proteins
Proteins that bind to thyroid hormones, helping in their transport and regulation in the body.
Thyroid Hormones
Hormones produced by the thyroid gland, including thyroxine and triiodothyronine, vital for regulating metabolism, energy, and growth and development.
Nuclear Receptor
A type of protein within cells that binds to specific molecules and influences the expression of genes, critical for various biological processes.
Messenger RNA
A type of RNA that carries genetic information from DNA to the protein-making sites in cells, guiding the synthesis of proteins.
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