Examine the Three Sequences Below for Collagen-Like Proteins

question 13

Multiple Choice

Examine the three sequences below for collagen-like proteins.If hydrogen bonding were the most important feature in determining strength in fibrous proteins,which of the following sequences likely has the highest melting temperature and why? (Note: Flp = fluoroproline;Hyp = hydroxyproline)
(I) Pro-Hyp-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly
(II) Pro-Flp-Gly-Pro-Flp-Gly-Pro-Flp-Gly
(III) Gly-Pro-Thr-Gly-Pro-Thr-Gly-Pro-Thr

• A)"1" because Hyp has OH groups
• B)"1" because the electronegativity of oxygen is greater
• C)"2" because the electronegativity of proline is greater
• D)"2" because the electronegativity of the -OH group increases hydrogen bond strength
• E)"3" because Thr is a small amino acid which allows close packing

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