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Which of the following is true regarding the reaction shown below?
Pyruvate + HCO3− + ATP oxaloacetate + ADP + Pi
(I) It requires the direct transport of oxaloacetate across the membrane.
(II) It utilizes the malate-aspartate shuttle in some species.
(III) It is essential for gluconeogenesis.
(IV) Its reactants require the function of enzymes which are only found in the cytosol.
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