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Which of the following is (are) characteristic of the (Na+-K+) -ATPase?
(I) It binds Na+ and K+ simultaneously prior to binding ATP
(II) It is covalently modified by phosphorylation at an Asp residue when Na+ is present.
(III) Transport of Na+ and K+ occur in a 1:1 ratio,thus maintaining a balanced gradient until opening of the gated portion of the channel.
(IV) It is essential for excitation of nerve cells.
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