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ClC Cl- channels
(I) assist in transport by forming a strong electrical dipole with the N-terminal end positively charged.
(II) effectively funnel ions into the pore via electrostatic interactions with basic amino acids.
(III) have a selectivity filter constructed from the N-terminal ends of α-helices,whose dipoles attract Cl- ions.
(IV) rely on the side chain hydroxyl groups from Ser and Tyr.
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