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The Imidazole Side Chain of Histidine Can Function as Either

question 15

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The imidazole side chain of histidine can function as either a general acid catalyst or a general base catalyst because
(I) the imidazole group has a pKa in the physiological pH range.
(II) in the physiological pH range,the nitrogen in the ring can be easily protonated/deprotonated.
(III) one guanidino group is protonated,and the other is deprotonated at physiological pH.
(IV) the imidazole group is a strong reducing agent at physiological pH.

Determine the overhead cost assigned to products under ABC.
Calculate product margins using ABC information.
Analyze the distribution of resource consumption across activity cost pools.
Understand the principles and application of activity-based costing (ABC) in allocating overhead costs to products.

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