A Recent Discovery Has Suggested That a Gene Mutation Results

question 49

Multiple Choice

A recent discovery has suggested that a gene mutation results in several amino acid substitutions within an active site.The following substitutions have been identified and are each expected to form the active site:

It was also noticed that a coenzyme molecule containing a hydroxyl (-OH) group binds to the mutated protein in approximately the same location as the original serine but does not alter the structure of the protein in anyway.Based on your knowledge of amino acids,enzymes,and catalysis,which of the following is a REASONABLE conclusion?

• A)The mutant protein cleaves on the carboxy side of phenylalanine.
• B)The mutant protein cleaves peptide bonds on the carboxy side of glutamate or aspartate.
• C)The mutant protein cleaves peptide bonds on the carboxy side of lysine or arginine.
• D)The mutant protein functions identical to chymotrypsin.
• E)The mutant protein has no function.

---

Definitions:

PGAL

Phosphoglyceraldehyde, a three-carbon molecule that is an important intermediate in the photosynthetic conversion of carbon dioxide into glucose as well as in glycolysis.

Phosphoglyceraldehyde

An intermediary compound in glycolysis and photosynthesis, playing a critical role in the metabolic pathways that generate energy and organic molecules.

Light-Dependent Reactions

These are the initial phase of photosynthesis, where light energy is captured and used to produce ATP and NADPH, which are necessary for the subsequent light-independent reactions.