Autoinhibition in the SH2 and SH3 Domains

question 27

Multiple Choice

Autoinhibition in the SH2 and SH3 domains

• A)occurs when a SH2 phospho-Tyr forms a salt bridge with an Arg on SH3.
• B)occurs when a SH2 phospho-Tyr binds a Pro segment on the SH3 domain,therefore blocking the active site and burying the required Tyr.
• C)occurs when a salt bride forms between the active site phosphor-Tyr on SH3 and the Glu on the activation loop.
• D)occurs when the salt bridge between Glu and Arg is broken.
• E)None of the above is correct.

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