The Anticancer Drug Methotrexate Inhibits Nucleotide Synthesis

question 9

Multiple Choice

The anticancer drug methotrexate inhibits nucleotide synthesis.Which of the following explains why it also inhibits the synthesis of histidine and methionine?

• A)The synthetic pathways for these amino acids require tetrahydrofolate for group transfer reactions.
• B)These amino acids are derivatives of the nucleotides UTP and GTP.
• C)Without the synthesis of nucleotides,there is not sufficient energy for the synthesis of the amino acids.
• D)<ethotrexate inhibits also inhibits the precursors for these amino acids.
• E)all of the above

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