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Which of the following is/are true about the relationship between chloride (Cl-) and bicarbonate HCO3- in acid-base balance?
1) For each Cl- ion excreted into the urine, the blood gains an HCO3- ion.
2) Blood Cl- and HCO3- ion levels are reciprocally related.
3) People with chronically high CO2 tend to have low blood Cl- levels.
4) Activation of the NH3 buffer system enhances Cl- gain and HCO3 loss.
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