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Which of the following indicate severely impaired oxygenation requiring high FiO2s and positive end expiratory pressure?
1) PaO2-PaO2 greater than 350 mm Hg on 100% O2
2) VC less than 10 ml/kg
3) PaO2/FiO2 less than 200
4) PaCO2 greater than 45 mm Hg
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