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A patient receiving continuous mandatory ventilation in the assist-control mode develops auto-PEEP. Which of the following changes in ventilatory patterns would you consider to minimize the effects of auto-PEEP in this patient?
1) Decreasing the rate or increasing VT
2) Using low-rate synchronized intermittent mandatory ventilation
3) Decreasing the peak inspiratory flow
4) Lowering the VT and letting the PaCO2 rise
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