The Step in Solid-Phase Peptide Synthesis That Occurs at Number

question 90

Multiple Choice

The step in solid-phase peptide synthesis that occurs at number 2 is

• A) deblocking of the residue attached to the resin.
• B) coupling of the amino acid.
• C) cleavage from the resin.
• D) activation of the Fmoc blocked residue.

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Definitions:

Carboxylation

A chemical reaction that introduces a carboxyl group (-COOH) into a molecule.

Grignard Reagent

An organomagnesium compound used in organic chemistry for carbon-carbon bond formation, represented as RMgX where R is an alkyl or aryl group and X is a halogen.

Organic Halide

An organic compound containing one or more halogen atoms (fluorine, chlorine, bromine, or iodine) covalently bonded to carbon.

Carboxylation

The chemical process of adding a carboxyl group (-COOH) to a molecule, often important in biosynthetic pathways.