Decide If the Rate of Malate Transport by the Omp32

question 95

Essay

Decide if the rate of malate transport by the Omp32 protein of Delftia acidovorans will be affected if the pH of the system is changed from 6.8 to 8.2.Explain your reasoning.
The pKa of amino acids with ionizable side chains are provided in the table below.Note that malic acid contains two ionizable groups with pKa of 3.40 and 5.20.Assume in this scenario that the pH change does not alter the overall conformation of the protein.

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