Decide if the rate of malate transport by the Omp32 protein of Delftia acidovorans will be affected if the pH of the system is changed from 6.8 to 8.2.Explain your reasoning.
The pKa of amino acids with ionizable side chains are provided in the table below.Note that malic acid contains two ionizable groups with pKa of 3.40 and 5.20.Assume in this scenario that the pH change does not alter the overall conformation of the protein. 
Definitions:
Reticular Formation
A network of nerve pathways in the brainstem that mediates the overall level of consciousness.
Medulla
A section of the brainstem responsible for regulating vital bodily functions such as breathing, heart rate, and blood pressure.
Pons
A part of the brainstem that plays a key role in controlling breathing, communication between different parts of the brain, and sensations such as hearing, taste, and balance.
Cerebellum
The part of the brain at the back of the skull in vertebrates, responsible for regulating motor movements, including coordination, precision, and timing.
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