How Would an Increased Level of Acetyl-CoA Be Expected to Affect

question 28

Multiple Choice

How would an increased level of acetyl-CoA be expected to affect the pyruvate dehydrogenase reaction?

• A) The pyruvate dehydrogenase kinase enzyme activity would increase, resulting in an inhibition of pyruvate dehydrogenase activity.
• B) The last step of the pyruvate dehydrogenase reaction would be blocked, resulting in a decrease in activity.
• C) The E1 subunit would be phosphorylated by pyruvate dehydrogenase kinase, and the catalytic activity of pyruvate dehydrogenase would decrease.
• D) The pyruvate dehydrogenase phosphatase-1 enzyme would increase, resulting in pyruvate dehydrogenase activation at an accelerated rate.

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