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A 1-Year-Old Boy Is Evaluated for a Suspected Immune Deficiency

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A 1-year-old boy is evaluated for a suspected immune deficiency.He has a history since birth of eczema,recurrent rashes,and diarrhea.(Normal values are given in parentheses.) His WBC count is 6.75/uL (5.0-10.8 × 103 uL) with a normal differential.Platelet count is 35,000 (150,000-350,000/uL) and the platelets are small.His IgG is 750 mg/dL (600-1,500 mg/dL) ,IgM is 30 mg/dL (75-150 mg/d:) ,IgA is 475 mg/dL (50-125 mg/dL) ,and IgE is 750 mg/dL (10-50 mg/dL) .The boy's blood is typed as O-positive,and he does not have anti-A or anti-B antibodies.Flow cytometry performed on his blood shows 11% (5-20%) CD19 and 50% (60-80%) CD3 cells with a normal ratio of CD4:CD8.T-cell function tests are abnormal.This boy most likely has:


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Union

An organization of workers formed to protect and advance their rights and interests; also refers to the act of uniting or the state of being united.

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A tax imposed by the government directly on individuals' or entities' income.

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The 16th President of the United States, Abraham Lincoln, who led the nation during the Civil War and is known for issuing the Emancipation Proclamation.

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