Which of the Following Is a Proposed Theory for Methyldopa-Induced

question 12

Multiple Choice

Which of the following is a proposed theory for methyldopa-induced mechanism of immune hemolytic anemia?

• A) Normal red blood cell antigens are altered by the drug and are no longer recognized as "self," resulting in production of alloantibody to these red blood cell antigens.
• B) The drug affects the synthesis of IgG, exerting a direct effect on T lymphocytes, which results in a loss of suppressor function and subsequent proliferation of autoantibodies by B lymphocytes.
• C) The drug produces aberrations in the proliferation of normal lymphocytes, producing clones of normal immunologically competent cells, which produces antibody against foreign red blood cell antigens.
• D) The drug modifies the red blood cells so that plasma proteins bind to the membrane.

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