Interphase FISH Has Been Performed on a Patient Sample

question 21

Multiple Choice

Interphase FISH has been performed on a patient sample. With a chromosome 8 centromeric (CEP 8) probe, two signals are observed in each spread examined. A probe for the immunoglobulin heavy chain region on chromosome 14 gives two distinct signals per nucleus, and a probe for the myc gene on chromosome 8 gives two distinct signals per nucleus. Which of following interpretations is correct?

• A) The patient is normal.
• B) The patient has a t(14;8) translocation.
• C) The patient has a chromosome 8 deletion.
• D) The patient has a chromosome 8 insertion.

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Definitions:

Extraneous Solutions

Solutions that are found in the process of solving an equation but do not satisfy the original equation.

Extraneous Solutions

Solutions that emerge from the process of solving a problem but do not satisfy the original equation.

Extraneous Solutions

Answers that result from the equation-solving process but fail to meet the criteria of the initial equation.

Variation Terminology

Language and concepts used to describe how quantities change together.