A Doctor Is Concerned About the Possibility of APL Syndrome

question 2

Multiple Choice

A doctor is concerned about the possibility of aPL syndrome in her patient, who had a stroke when she was 23 years old. Which of the following lab results is consistent with aPL syndrome?

• A) APTT prolonged but corrects with both an immediate and an incubated mixing study. Dilute Russell viper venom time (dRVVT) within normal range.
• B) APTT within normal range, dRVVT within normal range, prothrombin time (PT) within normal range, aCL high titer once but normal 6 weeks later.
• C) APTT prolonged, APTT prolonged on mixing study, normal dRVVT, normal dilute prothrombin time (dPT), APTT corrects with addition of excess phospholipid. The same results occur with repeat testing 8 weeks later.
• D) Prolonged PT, prolonged APTT, both correct on their respective immediate and incubated mixing studies.
• E) Normal APTT and dRVVT, prolonged dPT. dPT still prolonged after addition of excess phospholipid.