-Norethindrone Is a Synthetic Steroid That Is Better Than Progesterone

question 34

Multiple Choice

-Norethindrone is a synthetic steroid that is better than progesterone in suppressing ovulation. What reagents (1-3) are required to convert norethindrone to the derivatives shown below?

• A) (1) H₂, Pd-C; (2) (CH₃)₂CHCH₂NH₂, NaBH₃CN; (3) a. O₃, b. Zn, DMS
• B) (1) H₂, Pd-C; (2) (CH₃)₂CHCH₂NH₂, mild acid; (3) a. O₃, b. Zn, DMS
• C) (1) a. LiAlH₄, b. H₂O; (2) (CH₃)₂CHCH₂NH₂, NaBH₃CN; (3) a. OsO₄, b. NaHSO₃
• D) (1) a. LiAlH₄, b. H₂O; (2) (CH₃)₂CHCH₂NH₂, mild acid; (3) a. OsO₄, b. NaHSO₃

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