Why Is an Amide Less Reactive to Nucleophilic Acyl Substitution

question 28

Multiple Choice

Why is an amide less reactive to nucleophilic acyl substitution than an acid chloride?

• A)Nitrogen is a better leaving group.
• B)Chloride is a better leaving group.
• C)Nitrogen donates more electron density into the carbonyl.
• D)The amide anion is less basic.

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