Refer to the Figure Showing the Tertiary Structure of a Section

question 208

Multiple Choice

Refer to the figure showing the tertiary structure of a section of a mouse protein, and the table below, showing changes to the stability of the protein for specific single amino acid substitutions. The numbers shown in the left column refer to the amino acid's position in the polypeptide chain.Which conclusion is consistent with these data?

• A) Large changes in sizes of amino acid side chains disrupt the tertiary structure in this region of the protein.
• B) The tertiary structure of this section of the protein is stabilized by salt bridges between amino acid residues.
• C) Disruption of hydrophobic interactions in this section of the protein leads to decreased stability of its tertiary structure.
• D) Protein stability does not change no matter what amino acid is inserted at certain positions in the polypeptide chain.
• E) Protein stability always decreases whenever any amino acid change is made at certain positions in the polypeptide chain.

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