Refer to the Table Below Summarizing Data Obtained from Mutation

question 50

Multiple Choice

Refer to the table below summarizing data obtained from mutation experiments on a protein enzyme. Specific amino acid substitutions were made at residue 107, which is occupied by a serine residue in the normal protein.After the mutant proteins were made and purified, their enzymatic activities were measured and expressed as a percentage of unmutated protein's enzyme activity.Which statement provides the most plausible explanation of why such widely different changes in activity of the enzyme were observed?

• A) Some mutations lead to disruption of an important salt bridge in the protein, while others do not.
• B) Some mutations insert hydrophilic residues into a hydrophobic region of the protein, while others do not.
• C) Some mutations insert very large residues into a region of the protein that can accommodate only small side chains, while others do not.
• D) Some mutations remove a hydroxyl group in the side chain of residue 107, while others do not.
• E) Some mutations replace a hydroxyl group with a basic group, while others replace a hydroxyl group with an acidic group.

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