Refer to the Figure and Table Below

question 187

Multiple Choice

Refer to the figure and table below. Vitamin B₁₂ is an essential vitamin that humans must acquire from their diets.Within the small intestine, vitamin B₁₂ is taken up by receptor-mediated endocytosis as shown in the figure.The protein labeled IF binds to vitamin B₁₂ molecules in the intestinal lumen, forming a complex.This complex is recognized by the IF receptor present on intestinal cells and stimulates endocytosis when it binds.Vitamin B₁₂ by itself does not bind to the receptor.Individuals known to carry a mutation in either the IF protein or the IF receptor are represented in the table, along with observations about whether symptoms of vitamin B₁₂ deficiency are present.If a drug molecule could be produced that would bind to vitamin B₁₂ and stimulate uptake by intestinal cells, which individual(s) would be expected to benefit, based on the information given?

• A) Individual 1 only
• B) Individual 2 only
• C) Individual 3 only
• D) Individuals 1 and 2 only
• E) Individuals 2 and 3 only

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