Refer to the Table Summarizing Information Collected from Acetyl CoA

question 104

Multiple Choice

Refer to the table summarizing information collected from acetyl CoA carboxylase, the enzyme that catalyzes the first committed step in the biosynthesis of fatty acids from acetyl CoA. In these samples, enzyme purified from rat adipose tissue was used.No other cellular components were present when the enzyme in buffer solution was tested as outlined in the table.Based on the results shown, which statement describes how citrate is likely involved in the regulation of acetyl CoA carboxylase?

• A) Citrate activates transcription of the gene encoding the enzyme to increase its levels in the cell.
• B) Citrate is an inhibitor of the enzyme, operating through a negative feedback mechanism.
• C) Citrate is an allosteric activator of the enzyme, shifting protein conformational change from an inactive to an active form.
• D) Citrate inhibits a phosphatase that shifts the enzyme from an inactive to an active conformation by removing a phosphate group covalently bound to the enzyme.
• E) Citrate activates a protein kinase that induces a shift in the protein shape to an active form through covalent modification.

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