An Individual Inherits Two Defective Copies of the MLH1 Gene

question 114

Multiple Choice

An individual inherits two defective copies of the MLH1 gene, a protein involved in mismatch repair of DNA during its replication.What do you predict will be the consequences of deficient mismatch repair upon DNA replication?

• A) The fidelity of DNA polymerase activity will be decreased.
• B) Mismatched nucleotides will no longer be detected by the replication complex.
• C) Ligase will not be able to repair nicks in the DNA.
• D) The excision repair proteins will no longer function.
• E) A higher frequency of mutations will become fixed in the newly synthesized strand.

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