Refer to the Table

question 189

Multiple Choice

Refer to the table. Alkaptonuria is an inborn error of metabolism, caused by defects in an enzyme in the pathway that breaks down tyrosine (see Section 14.1) .Humans who are homozygous for one of these mutations make nonfunctional enzyme and accumulate the enzyme's substrate, homogentisic acid, which causes their disease symptoms.In 1996, researchers in Spain cloned and sequenced the gene for the enzyme and characterized several mutant alleles.The table shows the wild-type coding strand sequence for part of the gene and the corresponding region from one of the mutant alleles.What type of mutation is this?

• A) Silent
• B) Nonsense
• C) Frame-shift
• D) Missense
• E) Reversion

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Definitions:

Counterargument Role

A role or approach in discussions or debates where an individual actively develops and presents arguments against a prevailing view or proposition, to test its validity.

Task-Oriented Conflicts

Conflicts arising from differences in opinions or approaches towards accomplishing a specific task or goal.

Escalation Of Commitment

A decision-making process where individuals or groups continue to invest in a decision despite new evidence suggesting it might be wrong.

Sunk Costs

Expenses that have already been incurred and cannot be recovered, which should not affect future decision-making but often do.