Chronic Myelogenous Leukemia (CML) Is Usually Caused by the Oncogene

question 232

Multiple Choice

Chronic myelogenous leukemia (CML) is usually caused by the oncogene BCR/ABL.This abnormal gene is the product of the fusion of part of a BCR gene with part of an ABL gene.The resulting protein has unregulated tyrosine kinase activity.The BCR and ABL genes are normally found on two different chromosomes, respectively 22 and 9.What type of mutation is required to generate the BCR/ABL fusion gene?

• A) Chromosomal inversions
• B) Chromosomal deletion
• C) Chromosomal transversions
• D) Chromosomal transitions
• E) Chromosomal translocation

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