Which Disease Would Be Most Difficult to Detect with Standard

question 3

Multiple Choice

Which disease would be most difficult to detect with standard pedigree analysis?

• A) A multifactorial disease
• B) A disease caused by a recessive loss-of-function point mutation
• C) A disease caused by a missense mutation
• D) A disease caused by a dominant gain-of-function point mutation
• E) A disease caused by a base deletion

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Definitions:

Nuclei

The plural of nucleus, referring to the membrane-bound organelles in cells that contain genetic material.

Cerebellum

A part of the brain located at the back of the skull, vital for coordinating movement and balance, and involved in learning motor behaviors.

Basal Ganglia

Nuclei at the base of the cerebrum involved in controlling motor functions.

Midbrain

A central part of the brainstem that plays a role in vision, hearing, motor control, sleep/wake, arousal, and temperature regulation.